Endocrine Abstracts

Critical clinical changes of pulmonary function and weight occur in patients with cystic fibrosis (CF) antecedent to the development of frank Diabetes Mellitus (DM). Impaired glucose tolerance (IGT) signifies diminished Insulin secretion and increased peripheral insulin resistance, correlating with worse clinical status, under nutrition and impaired pulmonary function. Insulin therapy has been associated with improvement in anthropometric data and an arrest in decline in force...

Diabetes Mellitus (DM) and Impaired Glucose Tolerance (IGT) in patients with cystic fibrosis(CF) signifies a six fold rise in mortality and is associated with declining pulmonary function. The pathophysiology is multifactorial but largely due to Insulinopenia which is due to global islet cell fibrosis and accompanied by loss of islet alpha cells. Insulin treatment improves weight, the bacterial milieu, and lung function but is associated with hypoglycaemia. These patients may ...

Locus-specific databases (LSDBs) have been recently developed in response to the increasing number of genetic changes reported in the human genome. LSDBs have been created for several genes implicated in endocrine syndromes, for example MEN1, VHL, RET, GNAS, PRKAR1A and the SDH subunits. Mutations in AIP are found in about 20% of familial isolated pituitary adenoma (FIPA) patients.The aim of this proj...